Telomere Shortening, Atherosclerosis, and Metabolic Syndrome
نویسندگان
چکیده
منابع مشابه
Telomere shortening, atherosclerosis, and metabolic syndrome.
This mechanism resembles inflammatory reactions to exogenous factors and the wound healing process (2). Dysfunction of vascular endothelial cells is thought to induce a cascade of pathologic reactions of cell groups mediated by the expression of adhesion molecules, resulting in infiltration of mononuclear cells, foam cell formation, promotion of thrombus formation, and disturbed relaxation of b...
متن کاملLongitudinal Associations Between Metabolic Syndrome Components and Telomere Shortening.
CONTEXT Deterioration of metabolic syndrome (MetS) has been associated with short telomere length (TL). Large-scale longitudinal studies with repeated measures of MetS and TL are lacking. OBJECTIVES We examined whether baseline MetS components predict TL over time, and whether deteriorations in MetS parallel telomere attrition. DESIGN AND SETTING Participants were part of The Netherlands St...
متن کاملTelomere shortening & metabolic/vascular diseases.
Telomeres are specialized DNA-protein structures located at the ends of eukaryotic chromosomes whose length is progressively reduced in most somatic cells during ageing. Over the past decade, emerging evidence has shown that the telomeres are essential regulators of cellular life span and chromosome integrity in a dynamic fashion. By inducing genomic instability, replicative senescence and apop...
متن کاملTelomere shortening and metabolic compromise underlie dystrophic cardiomyopathy.
Duchenne muscular dystrophy (DMD) is an incurable X-linked genetic disease that is caused by a mutation in the dystrophin gene and affects one in every 3,600 boys. We previously showed that long telomeres protect mice from the lethal cardiac disease seen in humans with the same genetic defect, dystrophin deficiency. By generating the mdx4cv/mTRG2 mouse model with "humanized" telomere lengths, t...
متن کاملMetabolic Syndrome, Inflammation and Atherosclerosis
The inflammatory component of atherogenesis has been increasingly recognized over the last decade. Inflammation participates in all stages of atherosclerosis, not only during initiation and during evolution of lesions, but also with precipitation of acute thrombotic complications. The metabolic syndrome is associated with increased risk for development of both cardiovascular disease and type-2 ...
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ژورنال
عنوان ژورنال: Internal Medicine
سال: 2003
ISSN: 0918-2918,1349-7235
DOI: 10.2169/internalmedicine.42.135